Orchestration of ErbB3 signaling through heterointeractions and homointeractions.

ABSTRACT: Members of the ErbB family of receptor tyrosine kinases are capable of both homointeractions and heterointeractions. Because each receptor has a unique set of binding sites for downstream signaling partners and differential catalytic activity, subtle shifts in their combinatorial interplay may have a large effect on signaling outcomes. The overexpression and mutation of ErbB family members are common in numerous human cancers and shift the balance of activation within the signaling network. Here we report the development of a spatial stochastic model that addresses the dynamics of ErbB3 homodimerization and heterodimerization with ErbB2. The model is based on experimental measures for diffusion, dimer off-rates, kinase activity, and dephosphorylation. We also report computational analysis

SUBMITTER: McCabe Pryor M 

PROVIDER: S-EPMC4710241 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature