Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway.

ABSTRACT: The integrity of epithelial tissue architecture is maintained through adherens junctions that are created through extracellular homotypic protein-protein interactions between cadherin molecules. Cadherins also provide an intracellular scaffold for the formation of a multiprotein complex that contains signaling proteins, including β-catenin. Environmental factors and controlled tissue reorganization disrupt adherens junctions by cleaving the extracellular binding domain and initiating a series of transcriptional events that aim to restore tissue homeostasis. However, it remains unclear how alterations in cell adhesion coordinate transcriptional events, including those mediated by β-catenin in this pathway. Here were used quantitative single-cell and population-level in vitro assays to quant

SUBMITTER: Klinke DJ 

PROVIDER: S-EPMC4710243 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature