Pravastatin to prevent recurrent fetal death in massive perivillous fibrin deposition of the placenta (MPFD).

ABSTRACT: Massive perivillous fibrin deposition of the placenta (MPFD) or maternal floor infarction (MFI) is a serious condition associated with recurrent complications including fetal death and severe fetal growth restriction. There is no method to evaluate the risk of adverse outcome in subsequent pregnancies, or effective prevention. Recent observations suggest that MFI is characterized by an imbalance in angiogenic/anti-angiogenic factors in early pregnancy; therefore, determination of these biomarkers may identify the patient at risk for recurrence. We report the case of a pregnant woman with a history of four consecutive pregnancy losses, the last of which was affected by MFI. Abnormalities of the anti-angiogenic factor, sVEGFR-1, and soluble endoglin (sEng) were detected early in the index pr

SUBMITTER: Chaiworapongsa T 

PROVIDER: S-EPMC4710361 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature