Ontology highlight
ABSTRACT:
SUBMITTER: Juliano JJ
PROVIDER: S-EPMC4710419 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
The American journal of tropical medicine and hygiene 20151026 1
Polymorphisms within Plasmodium falciparum vaccine candidate antigens have the potential to compromise vaccine efficacy. Understanding the allele frequencies of polymorphisms in critical binding regions of antigens can help in the designing of strain-transcendent vaccines. Here, we adopt a pooled deep-sequencing approach, originally designed to study P. falciparum drug resistance mutations, to study the diversity of two leading transmission-blocking vaccine candidates, Pfs25 and Pfs48/45. We seq ...[more]