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Common gamma chain cytokines in combinatorial immune strategies against cancer.

ABSTRACT: Common ? chain (?C) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy. In this review, we will focus on the ?C cytokines that demonstrate the greatest potential for immunotherapy, IL-2, IL-7, IL-15, and IL-21. We will briefly cover their biological function, potential applications in cancer therapy, and update on their use in combinatorial immune strategies for eradicating tumors and hematopoietic malignancies.

SUBMITTER: Pulliam SR 

PROVIDER: S-EPMC4710466 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Common gamma chain cytokines in combinatorial immune strategies against cancer.

Pulliam Stephanie R SR   Uzhachenko Roman V RV   Adunyah Samuel E SE   Shanker Anil A  

Immunology letters 20151117

Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy. In this review, we will focus on the γC cytokines that demonstrate the greatest potential for immunotherapy, IL-2, IL-7, IL-15, and IL-21. We will briefly cover their biological function, potential applications in can  ...[more]

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