Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data.

ABSTRACT:

Background

Cerebral cavernous malformations (CCMs) can cause symptomatic intracranial haemorrhage (ICH), but the estimated risks are imprecise and predictors remain uncertain. We aimed to obtain precise estimates and predictors of the risk of ICH during untreated follow-up in an individual patient data meta-analysis.

Methods

We invited investigators of published cohorts of people aged at least 16 years, identified by a systematic review of Ovid MEDLINE and Embase from inception to April 30, 2015, to provide individual patient data on clinical course from CCM diagnosis until first CCM treatment or last available follow-up. We used survival analysis to estimate the 5-year risk of symptomatic ICH due to CCMs (primary outcome), multivariable Cox regression to identify baseline p

SUBMITTER: Horne MA 

PROVIDER: S-EPMC4710581 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature