Smoking-Associated DNA Methylation Biomarkers and Their Predictive Value for All-Cause and Cardiovascular Mortality.

ABSTRACT:

Background

With epigenome-wide mapping of DNA methylation, a number of novel smoking-associated loci have been identified.

Objectives

We aimed to assess dose-response relationships of methylation at the top hits from the epigenome-wide methylation studies with smoking exposure as well as with total and cause-specific mortality.

Methods

In a population-based prospective cohort study in Germany, methylation was quantified in baseline blood DNA of 1,000 older adults by the Illumina 450K assay. Deaths were recorded during a median follow-up of 10.3 years. Dose-response relationships of smoking exposure with methylation at nine CpGs were modeled by restricted cubic spline regression. Associations of individual and aggregate methylation patterns with all-cause, cardiovascul

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4710597 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature