Effects of Crude Oil/Dispersant Mixture and Dispersant Components on PPARγ Activity in Vitro and in Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen.

ABSTRACT:

Background

The obesity pandemic is associated with multiple major health concerns. In addition to diet and lifestyle, there is increasing evidence that environmental exposures to chemicals known as obesogens also may promote obesity.

Objectives

We investigated the massive environmental contamination resulting from the Deepwater Horizon (DWH) oil spill, including the use of the oil dispersant COREXIT in remediation efforts, to determine whether obesogens were released into the environment during this incident. We also sought to improve the sensitivity of obesogen detection methods in order to guide post-toxicological chemical assessments.

Methods

Peroxisome proliferator-activated receptor gamma (PPARγ) transactivation assays were used to identify putative obesogens. So

SUBMITTER: Temkin AM 

PROVIDER: S-EPMC4710608 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature