Mitochondrial and energetic cardiac phenotype in hypothyroid rat. Relevance to heart failure.

ABSTRACT: Changes in thyroid status are associated with profound alterations in biochemical and physiological functioning of cardiac muscle, although its impact on cardiac energy metabolism is still debated. Similarities between the changes in cardiac gene expression in pathological hypertrophy leading to heart failure and hypothyroidism prompted scientists to suggest a role for thyroid hormone status in the development of metabolic and functional alterations in this disease. We thus investigated the effects of hypothyroidism on cardiac energy metabolism. Hypothyroid state (HYPO) was induced by thyroidectomy and propyl-thio-uracyl in male rats for 3 weeks. We examined the effects of hypothyroid state on oxidative capacity and mitochondrial substrate utilization by measuring oxygen consumption of sap

SUBMITTER: Athea Y 

PROVIDER: S-EPMC4710782 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature