Glucagon increases energy expenditure independently of brown adipose tissue activation in humans.

ABSTRACT:

Aims

To investigate, for a given energy expenditure (EE) rise, the differential effects of glucagon infusion and cold exposure on brown adipose tissue (BAT) activation in humans.

Methods

Indirect calorimetry and supraclavicular thermography was performed in 11 healthy male volunteers before and after: cold exposure; glucagon infusion (at 23 °C); and vehicle infusion (at 23 °C). All volunteers underwent (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/CT scanning with cold exposure. Subjects with cold-induced BAT activation on (18)F-FDG PET/CT (n = 8) underwent a randomly allocated second (18)F-FDG PET/CT scan (at 23 °C), either with glucagon infusion (n = 4) or vehicle infusion (n = 4).

Results

We observed that EE increased by 14% after cold exp

SUBMITTER: Salem V 

PROVIDER: S-EPMC4710848 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature