IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation.

ABSTRACT:

Background

The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune cell epigenomes to engage specific differentiation states. Human monocytes differentiate under inflammatory conditions into effector cells with non-redundant functions, such as dendritic cells and macrophages. In this context, interleukin 4 (IL-4) and granulocyte macrophage colony-stimulating factor (GM-CSF) drive dendritic cell differentiation, whereas GM-CSF alone leads to macrophage differentiation.

Results

Here, we investigate the role of IL-4 in directing functionally relevant dendritic-cell-specific DNA methylation changes. A comparison of DNA methylome

SUBMITTER: Vento-Tormo R 

PROVIDER: S-EPMC4711003 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature