Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study.

ABSTRACT:

Background

The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one's subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one in caspase-8 (CASP8), have been previously associated with risk of developing breast cancer. Because caspase-8 is an important protein involved in receptor-mediated apoptosis whose activity is affected by estrogen, we hypothesized that additional SNPs in CASP8 could be associated with breast cancer risk, perhaps in a subtype-specific manner.

Methods

Twelve tagging SNPs of CASP8 were analyzed in a nested case control study (1,353 cases and 1,384 controls) of non-Hispanic white wome

SUBMITTER: Park HL 

PROVIDER: S-EPMC4711015 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature