Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster.

ABSTRACT:

Background

In models extensively used in studies of aging and extended lifespan, such as C. elegans and Drosophila, adult senescence is regulated by gene networks that are likely to be similar to ones that underlie lifespan extension during dormancy. These include the evolutionarily conserved insulin/IGF, TOR and germ line-signaling pathways. Dormancy, also known as dauer stage in the larval worm or adult diapause in the fly, is triggered by adverse environmental conditions, and results in drastically extended lifespan with negligible senescence. It is furthermore characterized by increased stress resistance and somatic maintenance, developmental arrest and reallocated energy resources. In the fly Drosophila melanogaster adult reproductive diapause is additionally manifested in arr

SUBMITTER: Kucerova L 

PROVIDER: S-EPMC4711038 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature