Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS.

ABSTRACT:

Introduction

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease with a gender bias towards major prevalence in male individuals. Several data suggest the involvement of oxidative stress and mitochondrial dysfunction in its pathogenesis, though differences between genders have not been evaluated. For this reason, we analysed features of mitochondrial oxidative metabolism, as well as mitochondrial chain complex enzyme activities and protein expression, lipid profile, and protein oxidative stress markers, in the Cu,Zn superoxide dismutase with the G93A mutation (hSOD1-G93A)- transgenic mice and Neuro2A(N2A) cells overexpressing hSOD1-G93A.

Results and conclusions

Our results show that overexpression of hSOD1-G93A in transgenic mice decreased efficiency of mitochondri

SUBMITTER: Cacabelos D 

PROVIDER: S-EPMC4711180 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature