Device-Based Approaches to Modulate the Autonomic Nervous System and Cardiac Electrophysiology.

ABSTRACT: Alterations in resting autonomic tone can be pathogenic in many cardiovascular disease states, such as heart failure and hypertension. Indeed, autonomic modulation by way of beta-blockade is a standard treatment of these conditions. There is a significant interest in developing non-pharmacological methods of autonomic modulation as well. For instance, clinical trials of vagal stimulation and spinal cord stimulation in the treatment of heart failure are currently underway, and renal denervation has been studied recently in the treatment of resistant hypertension. Notably, autonomic stimulation is also a potent modulator of cardiac electrophysiology. Manipulating the autonomic nervous system in studies designed to treat heart failure and hypertension have revealed that autonomic modulation m

SUBMITTER: Hucker WJ 

PROVIDER: S-EPMC4711497 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature