Allopurinol Resistance in Leishmania infantum from Dogs with Disease Relapse.

ABSTRACT:

Background

Visceral leishmaniasis caused by the protozoan Leishmania infantum is a zoonotic, life threatening parasitic disease. Domestic dogs are the main peridomestic reservoir, and allopurinol is the most frequently used drug for the control of infection, alone or in combination with other drugs. Resistance of Leishmania strains from dogs to allopurinol has not been described before in clinical studies.

Methodology/principal findings

Following our observation of clinical disease relapse in dogs under allopurinol treatment, we tested susceptibility to allopurinol of L. infantum isolated from groups of dogs pre-treatment, treated in remission, and with disease relapse during treatment. Promastigote isolates obtained from four treated relapsed dogs (TR group) showed an avera

SUBMITTER: Yasur-Landau D 

PROVIDER: S-EPMC4711794 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature