Ontology highlight
ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC4711820 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Nature biotechnology 20151214 1
Serotonin neurons located in the raphe nucleus of the hindbrain have crucial roles in regulating brain functions and have been implicated in various psychiatric disorders. Yet functional human serotonin neurons are not available for in vitro studies. Through manipulation of the WNT pathway, we demonstrate efficient differentiation of human pluripotent stem cells (hPSCs) to cells resembling central serotonin neurons, primarily those located in the rhombomeric segments 2-3 of the rostral raphe, wh ...[more]