Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.

ABSTRACT: Retinal transplantation therapy for retinitis pigmentosa is increasingly of interest due to accumulating evidence of transplantation efficacy from animal studies and development of techniques for the differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells into retinal tissues or cells. In this study, we aimed to assess the potential clinical utility of hESC-derived retinal tissues (hESC-retina) using newly developed primate models of retinal degeneration to obtain preparatory information regarding the potential clinical utility of these hESC-retinas in transplantation therapy. hESC-retinas were first transplanted subretinally into nude rats with or without retinal degeneration to confirm their competency as a graft to mature to form highly specified outer s

SUBMITTER: Shirai H 

PROVIDER: S-EPMC4711854 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature