A comparison of the mouse and human lipoproteome: suitability of the mouse model for studies of human lipoproteins.

ABSTRACT: Plasma levels of low density lipoproteins (LDL) and high density lipoproteins (HDL) exhibit opposing associations with cardiovascular disease in human populations and mouse models have been heavily used to derive a mechanistic understanding of these relationships. In humans, recent mass spectrometry studies have revealed that the plasma lipoproteome is significantly more complex than originally appreciated. This is particularly true for HDL which contains some 90 distinct proteins, a majority of which play functional roles that go beyond those expected for simple lipid transport. Unfortunately, the mouse lipoproteome remains largely uncharacterized-a significant gap given the heavy reliance on the model. Using a gel filtration chromatography and mass spectrometry analysis that targets phos

SUBMITTER: Gordon SM 

PROVIDER: S-EPMC4712022 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature