Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction.

ABSTRACT:

Background

Nitrates are commonly prescribed to enhance activity tolerance in patients with heart failure and a preserved ejection fraction. We compared the effect of isosorbide mononitrate or placebo on daily activity in such patients.

Methods

In this multicenter, double-blind, crossover study, 110 patients with heart failure and a preserved ejection fraction were randomly assigned to a 6-week dose-escalation regimen of isosorbide mononitrate (from 30 mg to 60 mg to 120 mg once daily) or placebo, with subsequent crossover to the other group for 6 weeks. The primary end point was the daily activity level, quantified as the average daily accelerometer units during the 120-mg phase, as assessed by patient-worn accelerometers. Secondary end points included hours of activity per

SUBMITTER: Redfield MM 

PROVIDER: S-EPMC4712067 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature