Telomere length is a prognostic biomarker in elderly advanced ovarian cancer patients: a multicenter GINECO study.

ABSTRACT:

Purpose

Age induces a progressive decline in functional reserve and impacts cancer treatments. Telomere attrition leads to tissue senescence. We tested the hypothesis that telomere length (TL) could predict patient vulnerability and outcome with cancer treatment.

Patients and methods

An ancillary study in the Elderly Women GINECO Trial 3 was performed to evaluate the impact of geriatric covariates on survival in elderly advanced ovarian cancer patients receiving six cycles of carboplatin. TL was estimated from peripheral blood at inclusion using standard procedures.

Results

TL (in base pairs) was estimated for 109/111 patients (median 6.1 kb; range [4.5-8.3 kb]). With a cut-off of 5.77 kb, TL discriminated two patient groups, long telomere (LT) and short telomeres (ST

SUBMITTER: Falandry C 

PROVIDER: S-EPMC4712332 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature