Reconstruction of temporal activity of microRNAs from gene expression data in breast cancer cell line.

ABSTRACT:

Background

MicroRNAs (miRNAs) are small non-coding RNAs that regulate genes at the post-transcriptional level in spatiotemporal manner. Several miRNAs are identified as prognostic and diagnostic markers in many human cancers. Estimation of the temporal activities of the miRNAs is an important step in the way to understand the complex interactions of these important regulatory elements with transcription factors (TFs) and target genes (TGs). However, current research on miRNA activities excludes network dynamics from the studies, disregarding the important element of time in the regulatory network analysis.

Results

In the current study, we combined experimentally verified miRNA-TG interactions with breast cancer microarray TG expression data to identify key miRNAs and compute

SUBMITTER: Jayavelu ND 

PROVIDER: S-EPMC4712512 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature