Association of MMP-2 gene haplotypes with thoracic aortic dissection in chinese han population.

ABSTRACT:

Background

Thoracic aortic dissection (TAD) is the most common life-threatening disorder, and MMP-2 is involved in TAD pathogenesis. Our purpose is to systematically evaluate the association of the MMP-2 gene with TAD risk in Chinese Han population.

Methods

In our case-control study, we recruited 755 unrelated participants: 315 case participants with TAD and 440 controls. Twenty-two tag SNPs were selected from MMP-2 gene and were genotyped. Genotype data were analyzed by logistic regression.

Results

Although we did not find any significant association for MMP-2 SNPs using single-marker analysis, we identified many windows with haplotype frequencies significantly different between case participants and control participants using a variable-sized sliding-window strategy

SUBMITTER: Liu O 

PROVIDER: S-EPMC4712614 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature