Ontology highlight
ABSTRACT:
SUBMITTER: Ablack JN
PROVIDER: S-EPMC4712820 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Journal of cell science 20151022 23
CD98 heavy chain (SLC3A2) facilitates lymphocyte clonal expansion that enables adaptive immunity; however, increased expression of CD98 is also a feature of both lymphomas and leukemias and represents a potential therapeutic target in these diseases. CD98 is transcriptionally regulated and ectopic expression of the membrane-associated RING-CH (MARCH) E3 ubiquitin ligases MARCH1 or MARCH8 leads to ubiquitylation and lysosomal degradation of CD98. Here, we examined the potential role of ubiquityla ...[more]