Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma.

ABSTRACT: Retinal development requires precise temporal and spatial coordination of cell cycle exit, cell fate specification, cell migration and differentiation. When this process is disrupted, retinoblastoma, a developmental tumor of the retina, can form. Epigenetic modulators are central to precisely coordinating developmental events, and many epigenetic processes have been implicated in cancer. Studying epigenetic mechanisms in development is challenging because they often regulate multiple cellular processes; therefore, elucidating the primary molecular mechanisms involved can be difficult. Here we explore the role of Brg1 (Smarca4) in retinal development and retinoblastoma in mice using molecular and cellular approaches. Brg1 was found to regulate retinal size by controlling cell cycle length,

SUBMITTER: Aldiri I 

PROVIDER: S-EPMC4712833 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature