Transcription Factors Exhibit Differential Conservation in Bacteria with Reduced Genomes.

ABSTRACT: The description of transcriptional regulatory networks has been pivotal in the understanding of operating principles under which organisms respond and adapt to varying conditions. While the study of the topology and dynamics of these networks has been the subject of considerable work, the investigation of the evolution of their topology, as a result of the adaptation of organisms to different environmental conditions, has received little attention. In this work, we study the evolution of transcriptional regulatory networks in bacteria from a genome reduction perspective, which manifests itself as the loss of genes at different degrees. We used the transcriptional regulatory network of Escherichia coli as a reference to compare 113 smaller, phylogenetically-related γ-proteobacteria, includi

SUBMITTER: Galan-Vasquez E 

PROVIDER: S-EPMC4713081 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature