Sequential posttranslational modifications regulate PKC degradation.

ABSTRACT: Cross-talk among different types of posttranslational modifications (PTMs) has emerged as an important regulatory mechanism for protein function. Here we elucidate a mechanism that controls PKCα stability via a sequential cascade of PTMs. We demonstrate that PKCα dephosphorylation decreases its sumoylation, which in turn promotes its ubiquitination and ultimately enhances its degradation via the ubiquitin-proteasome pathway. These findings provide a molecular explanation for the activation-induced down-regulation of PKC proteins.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4713141 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature