Discovery of a new method for potent drug development using power function of stoichiometry of homomeric biocomplexes or biological nanomotors.

ABSTRACT:

Introduction

Multidrug resistance and the appearance of incurable diseases inspire the quest for potent therapeutics.

Areas covered

We review a new methodology in designing potent drugs by targeting multi-subunit homomeric biological motors, machines or complexes with Z > 1 and K = 1, where Z is the stoichiometry of the target, and K is the number of drugged subunits required to block the function of the complex. The condition is similar to a series electrical circuit of Christmas decorations: failure of one light bulb causes the entire lighting system to lose power. In most multi-subunit, homomeric biological systems, a sequential coordination or cooperative action mechanism is utilized, thus K equals 1. Drug inhibition depends on the ratio of drugged to non-drugged complex

SUBMITTER: Pi F 

PROVIDER: S-EPMC4713257 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature