Patterns of growth and tract formation during the early development of secondary lineages in the Drosophila larval brain.

ABSTRACT: The Drosophila brain consists of a relatively small number of invariant, genetically determined lineages which provide a model to study the relationship between gene function and neuronal architecture. In following this long-term goal, we reconstruct the morphology (projection pattern and connectivity) and gene expression patterns of brain lineages throughout development. In this article, we focus on the secondary phase of lineage morphogenesis, from the reactivation of neuroblast proliferation in the first larval instar to the time when proliferation ends and secondary axon tracts have fully extended in the late third larval instar. We have reconstructed the location and projection of secondary lineages at close (4 h) intervals and produced a detailed map in the form of confocal z-project

SUBMITTER: Lovick JK 

PROVIDER: S-EPMC4713354 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature