TLR4, NOD1 and NOD2 mediate immune recognition of putative newly identified periodontal pathogens.

ABSTRACT: Periodontitis is a polymicrobial inflammatory disease that results from the interaction between the oral microbiota and the host immunity. Although the innate immune response is important for disease initiation and progression, the innate immune receptors that recognize both classical and putative periodontal pathogens that elicit an immune response have not been elucidated. By using the Human Oral Microbe Identification Microarray (HOMIM), we identified multiple predominant oral bacterial species in human plaque biofilm that strongly associate with severe periodontitis. Ten of the identified species were evaluated in greater depth, six being classical pathogens and four putative novel pathogens. Using human peripheral blood monocytes (HPBM) and murine bone-marrow-derived macrophages (BMDM

SUBMITTER: Marchesan J 

PROVIDER: S-EPMC4713362 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature