Simulated Thrombin Generation in the Presence of Surface-Bound Heparin and Circulating Tissue Factor.

ABSTRACT: An expanded computational model of surface induced thrombin generation was developed that includes hemodynamic effects, 22 biochemical reactions and 44 distinct chemical species. Surface binding of factors V, VIII, IX, and X was included in order to more accurately simulate the formation of the surface complexes tenase and prothrombinase. In order to model these reactions, the non-activated, activated and inactivated forms were all considered. This model was used to investigate the impact of surface bound heparin on thrombin generation with and without the additive effects of thrombomodulin (TM). In total, 104 heparin/TM pairings were evaluated (52 under venous conditions, 52 under arterial conditions), the results demonstrating the synergistic ability of heparin and TM to reduce thrombin

SUBMITTER: Dydek EV 

PROVIDER: S-EPMC4713373 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature