CD40 -1C>T polymorphism and the risk of lung cancer in a Chinese population.

ABSTRACT:

Background

The co-stimulatory molecule CD40 plays an important role in anti-tumor responses by promoting cytotoxic T lymphocyte (CTL) activity and differentiation of helper T cells. Growing evidence suggests that single nucleotide polymorphisms (SNPs) in CD40 are associated with the susceptibility to cancer. This study investigated the association between the CD40 -1C/T SNP (rs1883832) and lung cancer in a Chinese population.

Methods

We conducted a hospital-based case-control study including 105 lung cancer patients and 109 healthy control subjects. The -1C/T SNP in CD40 was genotyped by the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP), and its association with lung cancer susceptibility was evaluated.

Results

The distribution of the g

SUBMITTER: Zhou G 

PROVIDER: S-EPMC4713647 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature