Genetic analysis of TNFST15 variants in ankylosing spondylitis.

ABSTRACT:

Aims

The purpose of this study was to explore the role of TNF-like ligand 1A (TL1A) gene (TNFST15) polymorphisms (rs3810936, rs7848647, and rs6478109) in the generation of ankylosing spondylitis (AS).

Methods

Polymerase chain reaction (PCR) and sequencing were used to conduct the genotyping of TNFSF15 polymorphisms in 113 AS patients and 120 healthy persons as the case and control groups. The frequencies comparison was performed by chi-square or t test between the two groups. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated to represent the correlation between TNFSF15 polymorphism and AS. Besides, genotypes distribution of the former in controls was checked by Hardy-Weinberg equilibrium (HWE).

Results

There was statistically significant difference

SUBMITTER: Wang NG 

PROVIDER: S-EPMC4713654 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature