Interleukin-16 rs4778889 polymorphism contributes to the development of renal cell cancer in a Chinese population.

ABSTRACT: We conducted a case-control study to assess the role of IL-16 rs4778889, rs11556218 and rs8034928 polymorphisms in the development of RCC. This case-control study included 181 patients with RCC and 278 control patients. The genotyping of IL-16 rs4778889, rs11556218 and rs8034928 polymorphisms were performed using polymerase chain reaction (PCR) combined with restriction fragment length polymorphism analysis. By χ(2) test, we found that patients with RCC were more likely to suffer from hypertension (χ(2) = 9.06, P = 0.003) and diabetes (χ(2) = 7.91, P = 0.005). By unconditional logistic regression analysis, the CC genotype of rs4778889 was associated with an increased risk of RCC compared to TT genotype, and the adjusted OR (95% CI) was 3.58 (1.59-8.31). In dominant model and recessive mode

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4713657 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature