Complex regulation of ADAR-mediated RNA-editing across tissues.

ABSTRACT:

Background

RNA-editing is a tightly regulated, and essential cellular process for a properly functioning brain. Dysfunction of A-to-I RNA editing can have catastrophic effects, particularly in the central nervous system. Thus, understanding how the process of RNA-editing is regulated has important implications for human health. However, at present, very little is known about the regulation of editing across tissues, and individuals.

Results

Here we present an analysis of RNA-editing patterns from 9 different tissues harvested from a single mouse. For comparison, we also analyzed data for 5 of these tissues harvested from 15 additional animals. We find that tissue specificity of editing largely reflects differential expression of substrate transcripts across tissues. We ident

SUBMITTER: Huntley MA 

PROVIDER: S-EPMC4714477 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature