Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia.

ABSTRACT: Reduced speed of cerebral information processing is a cognitive deficit associated with schizophrenia. Normal information processing speed (PS) requires intact white matter (WM) physiology to support information transfer. In a cohort of 107 subjects (47/60 patients/controls), we demonstrate that PS deficits in schizophrenia patients are explained by reduced WM integrity, which is measured using diffusion tensor imaging, mediated by the mismatch in WM/gray matter blood perfusion, and measured using arterial spin labeling. Our findings are specific to PS, and testing this hypothesis for patient-control differences in working memory produces no explanation. We demonstrate that PS deficits in schizophrenia can be explained by neurophysiological alterations in cerebral WM. Whether the dispropor

SUBMITTER: Wright SN 

PROVIDER: S-EPMC4714540 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature