BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression.

ABSTRACT:

Introduction

Brain-derived neurotrophic factor (BDNF) polymorphisms have been examined for their contribution toward depression with equivocal results. More homogeneous phenotypes might be used to improve our understanding of genetic liability to depression. The aim of our study was to (a) test for an association between the BDNF Val66Met polymorphism and childhood-onset melancholic depression and (b) to examine the interactive effects of stressful life events (SLE) and the Val66Met polymorphism on the risk of childhood-onset melancholic depression.

Materials and methods

A total of 583 depressed probands were involved in this study (162 of the melancholic subtype). Diagnoses were derived through the Interview Schedule for Children and Adolescents - Diagnostic Version and lif

SUBMITTER: Rimay T 

PROVIDER: S-EPMC4714603 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature