Rationale, design and methodology of the image analysis protocol for studies of patients with cerebral small vessel disease and mild stroke.

ABSTRACT:

Rationale

Cerebral small vessel disease (SVD) is common in ageing and patients with dementia and stroke. Its manifestations on magnetic resonance imaging (MRI) include white matter hyperintensities, lacunes, microbleeds, perivascular spaces, small subcortical infarcts, and brain atrophy. Many studies focus only on one of these manifestations. A protocol for the differential assessment of all these features is, therefore, needed.

Aims

To identify ways of quantifying imaging markers in research of patients with SVD and operationalize the recommendations from the STandards for ReportIng Vascular changes on nEuroimaging guidelines. Here, we report the rationale, design, and methodology of a brain image analysis protocol based on our experience from observational longitudinal stu

SUBMITTER: Valdes Hernandez Mdel C 

PROVIDER: S-EPMC4714639 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature