A Spatial Framework for Understanding Population Structure and Admixture.

ABSTRACT: Geographic patterns of genetic variation within modern populations, produced by complex histories of migration, can be difficult to infer and visually summarize. A general consequence of geographically limited dispersal is that samples from nearby locations tend to be more closely related than samples from distant locations, and so genetic covariance often recapitulates geographic proximity. We use genome-wide polymorphism data to build "geogenetic maps," which, when applied to stationary populations, produces a map of the geographic positions of the populations, but with distances distorted to reflect historical rates of gene flow. In the underlying model, allele frequency covariance is a decreasing function of geogenetic distance, and nonlocal gene flow such as admixture can be identifie

SUBMITTER: Bradburd GS 

PROVIDER: S-EPMC4714911 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature