Ontology highlight
ABSTRACT:
SUBMITTER: Dunyak BM
PROVIDER: S-EPMC4714926 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Dunyak Bryan M BM Nakamura Robert L RL Frankel Alan D AD Gestwicki Jason E JE
ACS chemical biology 20150902 11
In drug discovery, small molecules must often discriminate between healthy and diseased cells. This feat is usually accomplished by binding to a protein that is preferentially expressed in the target cell or on its surface. However, in many cases, the expression of an individual protein may not generate sufficient cyto-selectivity. Here, we demonstrate that bispecific molecules can better discriminate between similar cell types by exploiting their simultaneous affinity for two proteins. Inspired ...[more]