Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks.

ABSTRACT: The actin cytoskeleton--a complex, nonequilibrium network consisting of filaments, actin-crosslinking proteins (ACPs) and motors--confers cell structure and functionality, from migration to morphogenesis. While the core components are recognized, much less is understood about the behaviour of the integrated, disordered and internally active system with interdependent mechano-chemical component properties. Here we use a Brownian dynamics model that incorporates key and realistic features--specifically actin turnover, ACP (un)binding and motor walking--to reveal the nature and underlying regulatory mechanisms of overarching cytoskeletal states. We generate multi-dimensional maps that show the ratio in activity of these microscopic elements determines diverse global stress profiles and the in

SUBMITTER: Mak M 

PROVIDER: S-EPMC4714927 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature