Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.

ABSTRACT:

Background

Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease and ulcerative colitis. We undertook the largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between diseases.

Methods

This study included patients from 49 centres in 16 countries in Europe, North America, and Australasia. We applied the Montreal classification system of inflammatory bowel disease subphenotypes to 34,819 patients (19,713 wit

SUBMITTER: Cleynen I 

PROVIDER: S-EPMC4714968 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature