A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

ABSTRACT: Here, we present FissionNet, a proteome-wide binary protein interactome for S. pombe, comprising 2,278 high-quality interactions, of which ∼ 50% were previously not reported in any species. FissionNet unravels previously unreported interactions implicated in processes such as gene silencing and pre-mRNA splicing. We developed a rigorous network comparison framework that accounts for assay sensitivity and specificity, revealing extensive species-specific network rewiring between fission yeast, budding yeast, and human. Surprisingly, although genes are better conserved between the yeasts, S. pombe interactions are significantly better conserved in human than in S. cerevisiae. Our framework also reveals that different modes of gene duplication influence the extent to which paralogous proteins

SUBMITTER: Vo TV 

PROVIDER: S-EPMC4715267 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature