Drug discovery in ophthalmology: past success, present challenges, and future opportunities.

ABSTRACT:

Background

Drug discovery has undergone major transformations in the last century, progressing from the recognition and refinement of natural products with therapeutic benefit, to the systematic screening of molecular libraries on whole organisms or cell lines and more recently to a more target-based approach driven by greater knowledge of the physiological and pathological pathways involved. Despite this evolution increasing challenges within the drug discovery industry are causing escalating rates of failure of development pipelines.

Discussion

We review the challenges facing the drug discovery industry, and discuss what attempts are being made to increase the productivity of drug development, including a refocusing on the study of the basic biology of the disease, and an

SUBMITTER: Gower NJD 

PROVIDER: S-EPMC4715274 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature