Biological quality control for cardiopulmonary exercise testing in multicenter clinical trials.

ABSTRACT:

Background

Precision and accuracy assurance in cardiopulmonary exercise testing (CPET) facilitates multicenter clinical trials by maximizing statistical power and minimizing participant risk. Current guidelines recommend quality control that is largely based on precision at individual testing centers (minimizing test-retest variability). The aim of this study was to establish a multicenter biological quality control (BioQC) method that considers both precision and accuracy in CPET.

Methods

BioQC testing was 6-min treadmill walking at 20 W and 70 W (below the lactate threshold) with healthy non-smoking laboratory staff (15 centers; ~16 months). Measurements were made twice within the initial 4 weeks and quarterly thereafter. Quality control was based on: 1) within-center prec

SUBMITTER: Porszasz J 

PROVIDER: S-EPMC4715309 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature