Functional analysis of monoclonal antibodies against the Plasmodium falciparum PfEMP1-VarO adhesin.

ABSTRACT:

Background

Rosetting, namely the capacity of the Plasmodium falciparum-infected red blood cells to bind uninfected RBCs, is commonly observed in African children with severe malaria. Rosetting results from specific interactions between a subset of variant P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesins encoded by var genes, serum components and RBC receptors. Rosette formation is a redundant phenotype, as there exists more than one var gene encoding a rosette-mediating PfEMP1 in each genome and hence a diverse array of underlying interactions. Moreover, field diversity creates a large panel of rosetting-associated serotypes and studies with human immune sera indicate that surface-reacting antibodies are essentially variant-specific. To gain better insight into the in

SUBMITTER: Guillotte M 

PROVIDER: S-EPMC4715314 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature