Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma.

ABSTRACT:

Background

Hemangioma is a common benign tumor in the childhood; however our knowledge about the molecular mechanisms of hemangioma development and progression are still limited. Currently, microRNAs (miRNAs) have been shown as gene expression regulators with an important role in disease pathogenesis. Our goals were to identify miRNA-mRNA expression networks associated with infantile hemangioma.

Methods

We performed a meta-analysis of previously published gene expression datasets including 98 hemangioma samples. Deregulated genes were further used to identify microRNAs as potential regulators of gene expression in infantile hemangioma. Data were integrated using bioinformatics methods, and genes were mapped in proteins, which were then used to construct protein-protein inter

SUBMITTER: Bertoni N 

PROVIDER: S-EPMC4715339 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature