Circulating CD34+ progenitor cells and risk of mortality in a population with coronary artery disease.

ABSTRACT:

Rationale

Low circulating progenitor cell numbers and activity may reflect impaired intrinsic regenerative/reparative potential, but it remains uncertain whether this translates into a worse prognosis.

Objectives

To investigate whether low numbers of progenitor cells associate with a greater risk of mortality in a population at high cardiovascular risk.

Methods and results

Patients undergoing coronary angiography were recruited into 2 cohorts (1, n=502 and 2, n=403) over separate time periods. Progenitor cells were enumerated by flow cytometry as CD45(med+) blood mononuclear cells expressing CD34, with additional quantification of subsets coexpressing CD133, vascular endothelial growth factor receptor 2, and chemokine (C-X-C motif) receptor 4. Coefficient of variation

SUBMITTER: Patel RS 

PROVIDER: S-EPMC4715427 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature