Biologically meaningful expression profiling across species using heterologous hybridization to a cDNA microarray.

ABSTRACT:

Background

Unravelling the path from genotype to phenotype, as it is influenced by an organism's environment, is one of the central goals in biology. Gene expression profiling by means of microarrays has become very prominent in this endeavour, although resources exist only for relatively few model systems. As genomics has matured into a comparative research program, expression profiling now also provides a powerful tool for non-traditional model systems to elucidate the molecular basis of complex traits.

Results

Here we present a microarray constructed with approximately 4500 features, derived from a brain-specific cDNA library for the African cichlid fish Astatotilapia burtoni (Perciformes). Heterologous hybridization, targeting RNA to an array constructed for a different

SUBMITTER: Renn SC 

PROVIDER: S-EPMC471549 | biostudies-literature | 2004 Jul

REPOSITORIES: biostudies-literature