IgE antibodies, FcεRIα, and IgE-mediated local anaphylaxis can limit snake venom toxicity.

ABSTRACT:

Background

Type 2 cytokine-related immune responses associated with development of antigen-specific IgE antibodies can contribute to pathology in patients with allergic diseases and to fatal anaphylaxis. However, recent findings in mice indicate that IgE also can enhance defense against honeybee venom.

Objective

We tested whether IgE antibodies, IgE-dependent effector mechanisms, and a local anaphylactic reaction to an unrelated antigen can enhance defense against Russell viper venom (RVV) and determined whether such responses can be influenced by immunization protocol or mouse strain.

Methods

We compared the resistance of RVV-immunized wild-type, IgE-deficient, and Fcer1a-deficient mice after injection of a potentially lethal dose of RVV.

Results

A single prio

SUBMITTER: Starkl P 

PROVIDER: S-EPMC4715494 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature